A linkage analysis in two families with bilateral retinoblastoma


Emre S. , Sungur A., Hazar V., Bilgic S., Buyukpamukcu M., Gunalp I.

TURKISH JOURNAL OF PEDIATRICS, vol.38, no.4, pp.413-417, 1996 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 4
  • Publication Date: 1996
  • Title of Journal : TURKISH JOURNAL OF PEDIATRICS
  • Page Numbers: pp.413-417
  • Keywords: retinoblastoma, polymorphism, polymerase chain reaction, LOCUS, GENE, PCR

Abstract

Using polymerase chain reaction (PCR) amplification from blood samples, Xbal and BamHl polymorphisms were analyzed in two families with bilateral retinoblastoma. In one of the families it was predicted using the BamHl polymorphism that the 200 bp allele co-segregates with the disease. This family was uninformative for Xbal polymorphism. The second family was uninformative for both Xbal and BamHl polymorphism.