A linkage analysis in two families with bilateral retinoblastoma

Emre S., Sungur A., Hazar V., Bilgic S., Buyukpamukcu M., Gunalp I.

TURKISH JOURNAL OF PEDIATRICS, cilt.38, sa.4, ss.413-417, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 4
  • Basım Tarihi: 1996
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.413-417
  • Anahtar Kelimeler: retinoblastoma, polymorphism, polymerase chain reaction, LOCUS, GENE, PCR
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Using polymerase chain reaction (PCR) amplification from blood samples, Xbal and BamHl polymorphisms were analyzed in two families with bilateral retinoblastoma. In one of the families it was predicted using the BamHl polymorphism that the 200 bp allele co-segregates with the disease. This family was uninformative for Xbal polymorphism. The second family was uninformative for both Xbal and BamHl polymorphism.