The altered expression of perineuronal net elements during neural differentiation
CELLULAR & MOLECULAR BIOLOGY LETTERS, vol.23, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 23
- Publication Date: 2018
- Doi Number: 10.1186/s11658-018-0073-5
- Journal Name: CELLULAR & MOLECULAR BIOLOGY LETTERS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Hacettepe University Affiliated: Yes
Abstract
Background: Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles. Hyaluronan and proteoglycan link protein 1 (HAPLN1), tenascin-R (TNR) and aggrecan (ACAN) are key elements of PNNs. In diseases characterized by neuritogenesis defects, the expression of these proteins is known to be downregulated, suggesting that PNNs may have a role in neural differentiation.