The altered expression of perineuronal net elements during neural differentiation


Eskici N. F. , ERDEM ÖZDAMAR S. , DAYANGAÇ ERDEN D.

CELLULAR & MOLECULAR BIOLOGY LETTERS, vol.23, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23
  • Publication Date: 2018
  • Doi Number: 10.1186/s11658-018-0073-5
  • Title of Journal : CELLULAR & MOLECULAR BIOLOGY LETTERS

Abstract

Background: Perineuronal nets (PNNs), which are localized around neurons during development, are specialized forms of neural extracellular matrix with neuroprotective and plasticity-regulating roles. Hyaluronan and proteoglycan link protein 1 (HAPLN1), tenascin-R (TNR) and aggrecan (ACAN) are key elements of PNNs. In diseases characterized by neuritogenesis defects, the expression of these proteins is known to be downregulated, suggesting that PNNs may have a role in neural differentiation.