Red Blood Cell Distribution Width as a Non-Invasive Marker for the Assessment of Inflammation in Non-Alcoholic Steatohepatitis


DOĞAN S., Celikbilek M., ZARARSIZ G., DENİZ K., Sivgin S., GÜVEN K., ...More

HEPATO-GASTROENTEROLOGY, vol.62, no.138, pp.393-398, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 138
  • Publication Date: 2015
  • Doi Number: 10.5754/hge14991
  • Title of Journal : HEPATO-GASTROENTEROLOGY
  • Page Numbers: pp.393-398

Abstract

Background/Aims: The aim of this study was to assess the association between red cell distribution width and inflammation in biopsy proven non-alcoholic steatohepatitis. Methodology: Fifty four subjects with non-alcoholic steatohepatitis and thirty nine controls were enrolled for the study. Liver biopsy specimens were scored by using non-alcoholic fatty liver disease activity score by a single experienced liver pathologist. Results: Red cell distribution width was higher in the severe inflarnmation group in nonalcoholic steatohepatitis (p< 0.05). The areas under the receiver operating characteristic curves for the predictive performance of aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transferase and red cell distribution width in identifying inflammation in non-alcoholic steatohepatitis were 0.55 (0.41-0.68), 0.51 (0.37-0.64), 0.53 (0.39-0.67) and 0.73 (0.59-0.84) respectively and the differences of these values between red cell distribution width and other parameters were found to be statistically significant (p<0.05). To determine the grading of inflammation, the specificity for using the red cell distribution width as an indicator in non-alcoholic steatohepatitis patients was calculated to be 73.3%, with 79.5% sensitivity. Conclusion: Red cell distribution *kith was a sensitive and specific method for the assessment of the inflammation in patients with non-alcoholic steatohepatitis.