Lipidomic Research in Toxicology


Sabuncuoğlu S.

10th International Congress of the Turkish Society of Toxicology, Antalya, Turkey, 16 - 19 October 2019, pp.48

  • Publication Type: Conference Paper / Summary Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.48

Abstract

L40 - Lipidomic research in toxicologySuna SabuncuogluHacettepe University, Faculty of Pharmacy, Department of Toxicology, Sihhiye, Ankara-Turkeysuna@hacettepe.edu.trLipids are crucial components of living organisms and play many essential roles in cell, including barrier function, signalization, and energy metabolism. Lipidomics is a newly emerged discipline that studies cellular lipids on a large scale based on analytical chemistry principles and technological tools, particularly mass spectrometry. It is an important area in which toxicologists can play an important role. Toxic xenobiotics or nontoxic mediator responses are observed in transcription, translation, enzyme activity, and lipid composition. Possible changes in macromolecules including lipids may effect cellular functions. As it is known, oxidative lipid damage play an important role as mediators of many pathological conditions and of cellular homeostasis. Lipid oxidation products can cause oxidative stress and cell death. Oxidative lipid damage leads to progression of a number of diseases, such as heart disease, asthma, obstructive pulmonary disease, and Alzheimers disease, which have been found to be exacerbated by xenobiotic exposure. Oxidative lipid products contribute the elevation of inflammatory states and may be prognostic markers in a number of diseases that are affected by toxins. These substances are becoming recognized as important regulators of the disease processes controlled by toxic xenobiotics and involve distribution of crucial cellular pathways. For instance, isoprostanes have provided important prognostic markers, but other products may also be useful in various diseases. Oxysterols are other lipid group which consist of the oxidation of cholesterol and non-enzymatic (auto-oxidation) derivatives have been shown to be associated with many pathological conditions and used as a biomarker in particular disorders. A particular interest of toxicologists is the study of oxidative stress and inflammation. Lipidomic research in toxicology can contribute to determine the role of lipids in diseases and investigations on mechanistic toxicity of toxic chemicals.