Role of medullary excitatory amino acid receptors in mediating the 10-Hz rhythm in sympathetic nerve discharge of cats


Barman S., Orer H., Gebber G.

BRAIN RESEARCH, vol.1049, no.2, pp.249-253, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 1049 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1016/j.brainres.2005.05.018
  • Title of Journal : BRAIN RESEARCH
  • Page Numbers: pp.249-253

Abstract

We tested the hypothesis that excitatory amino acid (EAA)-mediated transmission plays a role in generating the 10-Hz rhythm in sympathetic nerve discharge (SND) of baroreceptor-denervated, urethane-anesthetized cats. Microinjection of either an N-methyl-D-aspartate (NMDA) or non-NMDA receptor antagonist into any one of three medullary regions (lateral tegmental field, rostra], or caudal ventrolateral medulla) essentially eliminated the 10-Hz rhythm in inferior cardiac SND. We conclude that EAA receptors in the medulla are critical for generation of the 10-Hz rhythm. (c) 2005 Elsevier B.V. All rights reserved.