The Causative Classification of Stroke system An international reliability and optimization study

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Arsava E. M., BALLABIO E., Benner T., COLE J. W., DELGADO-MARTINEZ M. P., DICHGANS M., ...More

NEUROLOGY, vol.75, no.14, pp.1277-1284, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75 Issue: 14
  • Publication Date: 2010
  • Doi Number: 10.1212/wnl.0b013e3181f612ce
  • Journal Name: NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1277-1284
  • Hacettepe University Affiliated: Yes


Background: Valid and reliable ischemic stroke subtype determination is crucial for well-powered multicenter studies. The Causative Classification of Stroke System (CCS, available at is a computerized, evidence-based algorithm that provides both causative and phenotypic stroke subtypes in a rule-based manner. We determined whether CCS demonstrates high interrater reliability in order to be useful for international multicenter studies.