Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations
MOVEMENT DISORDERS, vol.19, no.5, pp.544-548, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 19 Issue: 5
- Publication Date: 2004
- Doi Number: 10.1002/mds.10695
- Journal Name: MOVEMENT DISORDERS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.544-548
- Keywords: Parkinson's disease, complex I, complex IV, mDNA, ANTIOXIDANT DEFENSES, OXIDATIVE DAMAGE, NITRIC-OXIDE, PLATELETS, GENETICS, DISEASE, PATHOGENESIS, INHIBITION, DEPLETION, PATHWAY
- Hacettepe University Affiliated: Yes
Abstract
The parkin protein functions as a RING-type ubiquitin protein ligase. Considering the possibility that impaired ubiquitin-proteosomal system activity may impair antioxidant defenses and enhance oxidative stress, we have investigated the activity of mitochondrial respiratory enzymes in patients with parkin gene mutations. A significant decrease in the leukocyte complex I activity was found both in patients with parkin mutations (62.5%) and idiopathic PD (64.5%) compared with age-matched controls (P < 0.001). Complex IV activity was also decreased significantly in idiopathic PD patients (60%), but no difference was detected between controls and patients with parkin mutations. (C) 2003 Movement Disorder Society.