Resveratrol Protects Sepsis-Induced Oxidative DNA Damage in Liver and Kidney of Rats

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AYDIN DİLSİZ S., Sahin T. T., BACANLI M., Taner G., BAŞARAN A. A., AYDIN DİLSİZ S., ...More

BALKAN MEDICAL JOURNAL, vol.33, no.6, pp.594-601, 2016 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.5152/balkanmedj.2016.15516
  • Journal Name: BALKAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.594-601
  • Keywords: Resveratrol, sepsis, tumor necrosis factor alpha oxidative stress, DNA damage, alkaline single cell gel electrophoresis, HUMAN-LYMPHOCYTES, CRITICALLY-ILL, STRESS, PREVENTION, PARAMETERS, MELATONIN, INJURY, MOUSE, CELLS
  • Open Archive Collection: AVESIS Open Access Collection
  • Hacettepe University Affiliated: Yes

Abstract

Background: The increases of free radicals have been proposed to be involved in the pathogenesis of sepsis, which leads to multiple-organ dysfunction syndromes. The uses of antioxidants as a complementary tool in the medical care of oxidative stress-related diseases have attracted attention of researchers. Resveratrol (RV) has suggested being antioxidant, anti-proliferative, and anti-inflammatory effects in various experimental models and clinical settings.