A randomized, double-blind comparison of clozapine and high-dose olanzapine in treatment-resistant patients with schizophrenia

Meltzer H. Y., Bobo W. V., Roy A., Jayathilake K., Chen Y., ERTUĞRUL A., ...More

JOURNAL OF CLINICAL PSYCHIATRY, vol.69, no.2, pp.274-285, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.4088/jcp.v69n0214
  • Journal Name: JOURNAL OF CLINICAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.274-285
  • Hacettepe University Affiliated: Yes

Abstract

Background: Clozapine, despite its side-effect burden, has been considered to be the drug of choice for patients with schizophrenia whose psychotic symptoms fail to respond adequately to other antipsychotic drugs. There are conflicting data concerning the potential utility of olanzapine in treatment-resistant schizophrenia at doses beyond the 10- to 20-mg/day range that has proven to be effective for most nonrefractory patients with schizophrenia.