A randomized, double-blind comparison of clozapine and high-dose olanzapine in treatment-resistant patients with schizophrenia


Meltzer H. Y. , Bobo W. V. , Roy A., Jayathilake K., Chen Y., ERTUĞRUL A. , ...Daha Fazla

JOURNAL OF CLINICAL PSYCHIATRY, cilt.69, sa.2, ss.274-285, 2008 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Konu: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.4088/jcp.v69n0214
  • Dergi Adı: JOURNAL OF CLINICAL PSYCHIATRY
  • Sayfa Sayıları: ss.274-285

Özet

Background: Clozapine, despite its side-effect burden, has been considered to be the drug of choice for patients with schizophrenia whose psychotic symptoms fail to respond adequately to other antipsychotic drugs. There are conflicting data concerning the potential utility of olanzapine in treatment-resistant schizophrenia at doses beyond the 10- to 20-mg/day range that has proven to be effective for most nonrefractory patients with schizophrenia.