The effect of Pseudomonas aeruginosa eradication regimens on chronic colonization and clinical outcomes in pediatric patients with cystic fibrosis

Buyuksahin H. N., Yalcin E., EMİRALİOĞLU ORDUKAYA N., HAZIROLAN G., Tural D. A., Ozsezen B., ...More

PEDIATRICS INTERNATIONAL, vol.64, no.1, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1111/ped.15249
  • Journal Name: PEDIATRICS INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: body mass index, cystic fibrosis, lung function, Pseudomonas aeruginosa, LONGITUDINAL DEVELOPMENT, DORNASE-ALPHA, LUNG-FUNCTION, CHILDREN, INFECTION, ECFS, ACQUISITION, GUIDELINES, NUTRITION
  • Hacettepe University Affiliated: Yes

Abstract

Background: Chronic Pseudomonas aeruginosa colonization (Pa-CC) affects cystic fibrosis (CF) progression, including pulmonary exacerbations and pulmonary function tests. There are few studies of the effects of eradication protocols on colonization time. Here, we aimed to evaluate the effect of eradication regimens on chronic colonization and assess the impact of Pa-CC on body mass index, lung functions, and pulmonary exacerbations.