Systemic Administration of Interleukin-10 Attenuates Early Ischemic Response Following Spinal Cord Ischemia Reperfusion Injury in Rats

Oruckaptan H. H., Ozisik P., ATİLLA P., Tuncel M., Kilinc K., Geyik P., ...More

JOURNAL OF SURGICAL RESEARCH, vol.155, no.2, pp.345-356, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 155 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1016/j.jss.2008.07.013
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.345-356
  • Keywords: spinal cord, ischemia, reperfusion injury, cytokine, interleukin-10, interleukin-1 beta, inflammation, central nervous system, lipid peroxidation, myeloperoxidase, TUMOR-NECROSIS-FACTOR, CENTRAL-NERVOUS-SYSTEM, ANTIINFLAMMATORY CYTOKINE, AORTIC OCCLUSION, MESSENGER-RNA, BRAIN-INJURY, MYELOPEROXIDASE ACTIVITY, INFLAMMATORY CYTOKINES, CEREBRAL-ISCHEMIA, FOCAL STROKE
  • Hacettepe University Affiliated: Yes


Background. The aim of this experimental study was to investigate the early effects of interleukin-10 (IL-10) and interleukin-1 beta antagonist (anti-IL-1 beta) against cellular damage, inflammatory reactivity, lipid peroxidation (LPO), and myeloperoxidase (MPO) activity induced by spinal cord ischemia reperfusion injury (IRI).