Systemic Administration of Interleukin-10 Attenuates Early Ischemic Response Following Spinal Cord Ischemia Reperfusion Injury in Rats

Oruckaptan, H.; Ozisik, Pinar; ATİLLA, PERGİN; Tuncel, Muruvet; Kilinc, Kamer; Geyik, PINAR; Basaran, AYŞE; Yuksel, Eser; ÖZCAN, ÖZGÜR

doi:10.1016/j.jss.2008.07.013

Systemic Administration of Interleukin-10 Attenuates Early Ischemic Response Following Spinal Cord Ischemia Reperfusion Injury in Rats

Oruckaptan H. H., Ozisik P., ATİLLA P., Tuncel M., Kilinc K., Geyik P., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.155, sa.2, ss.345-356, 2009 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Derleme
Cilt numarası: 155 Sayı: 2
Basım Tarihi: 2009
Doi Numarası: 10.1016/j.jss.2008.07.013
Dergi Adı: JOURNAL OF SURGICAL RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.345-356
Anahtar Kelimeler: spinal cord, ischemia, reperfusion injury, cytokine, interleukin-10, interleukin-1 beta, inflammation, central nervous system, lipid peroxidation, myeloperoxidase, TUMOR-NECROSIS-FACTOR, CENTRAL-NERVOUS-SYSTEM, ANTIINFLAMMATORY CYTOKINE, AORTIC OCCLUSION, MESSENGER-RNA, BRAIN-INJURY, MYELOPEROXIDASE ACTIVITY, INFLAMMATORY CYTOKINES, CEREBRAL-ISCHEMIA, FOCAL STROKE
Hacettepe Üniversitesi Adresli: Evet

Özet

Background. The aim of this experimental study was to investigate the early effects of interleukin-10 (IL-10) and interleukin-1 beta antagonist (anti-IL-1 beta) against cellular damage, inflammatory reactivity, lipid peroxidation (LPO), and myeloperoxidase (MPO) activity induced by spinal cord ischemia reperfusion injury (IRI).