Systemic Administration of Interleukin-10 Attenuates Early Ischemic Response Following Spinal Cord Ischemia Reperfusion Injury in Rats

Oruckaptan, H.; Ozisik, Pinar; ATİLLA, PERGİN; Tuncel, Muruvet; Kilinc, Kamer; Geyik, PINAR; Basaran, AYŞE; Yuksel, Eser; ÖZCAN, ÖZGÜR

doi:10.1016/j.jss.2008.07.013

Systemic Administration of Interleukin-10 Attenuates Early Ischemic Response Following Spinal Cord Ischemia Reperfusion Injury in Rats

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Oruckaptan H. H., Ozisik P., ATİLLA P., Tuncel M., Kilinc K., Geyik P., ...More

JOURNAL OF SURGICAL RESEARCH, vol.155, no.2, pp.345-356, 2009 (SCI-Expanded)

Publication Type: Article / Review
Volume: 155 Issue: 2
Publication Date: 2009
Doi Number: 10.1016/j.jss.2008.07.013
Journal Name: JOURNAL OF SURGICAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.345-356
Keywords: spinal cord, ischemia, reperfusion injury, cytokine, interleukin-10, interleukin-1 beta, inflammation, central nervous system, lipid peroxidation, myeloperoxidase, TUMOR-NECROSIS-FACTOR, CENTRAL-NERVOUS-SYSTEM, ANTIINFLAMMATORY CYTOKINE, AORTIC OCCLUSION, MESSENGER-RNA, BRAIN-INJURY, MYELOPEROXIDASE ACTIVITY, INFLAMMATORY CYTOKINES, CEREBRAL-ISCHEMIA, FOCAL STROKE
Hacettepe University Affiliated: Yes

Abstract

Background. The aim of this experimental study was to investigate the early effects of interleukin-10 (IL-10) and interleukin-1 beta antagonist (anti-IL-1 beta) against cellular damage, inflammatory reactivity, lipid peroxidation (LPO), and myeloperoxidase (MPO) activity induced by spinal cord ischemia reperfusion injury (IRI).