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AMERICAN JOURNAL OF INFECTION CONTROL, vol.53, no.10, pp.1085-1090, 2025 (SCI-Expanded, Scopus)
Background: Central line-associated bloodstream infections (CLABSIs) in neonatal intensive care units (NICUs) significantly impact patient outcomes and health care costs. This study evaluates the effect of NICUspecific bundle designed to prevent CLABSIs. Methods: This retrospective single-center study was conducted at Hacettepe University Faculty of Medicine from March 2020 to August 2021. It was designed to compare 2 periods: pre-intervention and post-intervention period. Results: The implementation of the bundles led to a significant reduction in infection rates, with CLABSIs decreasing from 29 to 4 per 1,000 central line days in NICU-1 and from 14.2 to 2.6 per 1,000 central line days in NICU-2. This decline was accompanied by an 80% reduction in the average health care cost per patient. Conclusions: The implementation of a NICU-specific CLABSI prevention bundle significantly reduced infection rates and lowered health care costs by approximately 80% per patient. These findings highlight the effectiveness of structured, multidisciplinary infection control strategies in improving neonatal outcomes and resource utilization. (c) 2025 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.