Investigation of adsorption of metronidazole on Chitosan - Halloysite nanocomposites and controlled release

Oztekin M., SAĞ AÇIKEL Y.

INDIAN JOURNAL OF CHEMICAL TECHNOLOGY, vol.27, no.2, pp.101-115, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2020
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), Chemical Abstracts Core, Communication Abstracts, INSPEC, Metadex, Pollution Abstracts, Civil Engineering Abstracts
  • Page Numbers: pp.101-115
  • Hacettepe University Affiliated: Yes


A novel nanocomposite drug carrier composing from chitosan (CTN) and halloysite nanotubes (HNTs) has been developed. For this purpose, the metronidazole (MNZ) is chosen as a model drug. The characterization of synthesized nanocomposites is performed by FTIR, TGA, DSC, SEM, TEM, BET and particle size distribution analysis. MNZ is loaded to chitosan-halloysite (CTN-FINT) nanocomposites in two ways; by direct loading and adsorption method. The adsorption of MNZ on CTN-FINT nanocomposites have been investigated as a function of medium pH, mass ratio of CTN to halloysite (INT), amount of nanocomposite and drug concentration. The fit of MNZ adsorption equilibrium on CTN-FINT nanocomposites to the Langmuir and Freundlich models was investigated. The adsorption kinetics of MNZ on nanocomposites have been evaluated using the pseudo-first order rate equation of Lagergren and the pseudo-second-order rate equation of Mc-Kay and Ho. The controlled release of MNZ from CTN-FINT nanocomposites has also been investigated.