Hepatic cholesterol synthesis and lipoprotein levels impaired by dietary fructose and saturated fatty acids in mice: Insight on PCSK9 and CD36

Nergiz-Unal R., Ulug E., Kisioglu B., Tamer F., Bodur M., Yalcimin H., ...More

NUTRITION, vol.79-80, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 79-80
  • Publication Date: 2020
  • Doi Number: 10.1016/j.nut.2020.110954
  • Journal Name: NUTRITION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: CD36, PCSK9, Saturated fatty acids, Fructose, Cholesterol metabolism, CARDIOVASCULAR-DISEASE, THROMBUS FORMATION, LIPID PROFILE, LDL RECEPTOR, OLEIC-ACID, EXPRESSION, DEGRADATION, PLASMA, DYSFUNCTION, ASSOCIATION
  • Hacettepe University Affiliated: Yes

Abstract

Objectives: The aim of this study was to investigate the uncertain effects of high saturated fatty acids (SFAs) or fructose intake on cholesterol and lipoproteins with an insight of proprotein convertase subtilisin/kexin type 9 (PCSK9)- and cluster of differentiation 36 (CD36)-induced mechanisms.