International randomized phase 2 study on the addition of docetaxel to the combination of cisplatin and 5-fluorouracil in the induction treatment for nasopharyngeal carcinoma in children and adolescents


CASANOVA M., Ozyar E., PATTE C., ORBACH D., FERRARI A., VEYRAT-FOLLET C., ...More

CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol.77, no.2, pp.289-298, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1007/s00280-015-2933-2
  • Title of Journal : CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Page Numbers: pp.289-298

Abstract

Nasopharyngeal carcinoma (NPC) is a rare but aggressive malignancy in children and adolescents. An international, randomized phase 2 trial was conducted to compare induction chemotherapy with docetaxel plus cisplatin and 5-fluorouracil (TPF) with cisplatin and 5-fluorouracil (PF) in NPC patients under the age of 21.