International randomized phase 2 study on the addition of docetaxel to the combination of cisplatin and 5-fluorouracil in the induction treatment for nasopharyngeal carcinoma in children and adolescents

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CASANOVA M., Ozyar E., PATTE C., ORBACH D., FERRARI A., VEYRAT-FOLLET C., ...More

CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol.77, no.2, pp.289-298, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 77 Issue: 2
• Publication Date: 2016
• Doi Number: 10.1007/s00280-015-2933-2
• Journal Name: CANCER CHEMOTHERAPY AND PHARMACOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.289-298
• Hacettepe University Affiliated: Yes

Abstract

Nasopharyngeal carcinoma (NPC) is a rare but aggressive malignancy in children and adolescents. An international, randomized phase 2 trial was conducted to compare induction chemotherapy with docetaxel plus cisplatin and 5-fluorouracil (TPF) with cisplatin and 5-fluorouracil (PF) in NPC patients under the age of 21.