Intracavernous application of diazepam: An alternative route of the seizure treatment - an experimental study in rabbits


Dundaroz R., Degim T., Sizlan A., Yasar M., Denli M., Gokcay E.

PEDIATRICS INTERNATIONAL, vol.44, no.2, pp.163-167, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 2
  • Publication Date: 2002
  • Doi Number: 10.1046/j.1328-8067.2001.01530.x
  • Title of Journal : PEDIATRICS INTERNATIONAL
  • Page Numbers: pp.163-167

Abstract

Backround: There is a general need to terminate seizures as soon as possible using anticonvulsant drugs via an intravenous (i.v.) route, but it is often difficult to achieve a secure i.v. Line during the seizure, especially in children. However, it has been demonstrated that high volumes of fluid can be injected into the corpora cavernosa. The purpose of this study was to evaluate the absorption properties of diazepam (DZ) after intracavernous (i.c.) administration and whether therapeutically significant plasma concentrations can be obtained or not.