Considering the proven acute physiological and directly related consequences of exposure to pain at early stages of development, regional anaesthesia should be a part of pain management at every stage of childhood. Peripheral nerve blocks have gained wide use in the management of paediatric anaesthesia and analgesia, as they have been reported to have lower complication rates than central blocks especially for reduced morbidity and increased safety both at rest and on movement. The use of ultrasound for real-time visualization of the anatomical structures, advancement of needle and placement of the local anaesthetic into the correct anatomical site improved both the safety and efficacy profile of these block performances. Despite the technological improvements giving rise to safety issues and efficacy of these blocks, training on the use of this improving technology and studying the different physiology and anatomy of children at different stages of development still remain crucial. Although there is still need for standardized approaches described for peripheral nerve blocks in children at different age groups, the advantages such as decreasing exposure to opioids, suppressing the stress response, decreasing the doses of general anaesthetics, providing better hemodynamic stability cannot be denied. This review aims to highlight the peripheral nerve blocks which can be implemented as regional anaesthetic and analgesic techniques in infants and children undergoing general paediatric surgical procedures, excluding the orthopaedic surgeries and trauma.