Novel Coronavirus Disease (COVID-19) raised many questions needing answers in order to overcome the disease burden globally. Uncertainty about COVID-19 contributes to the complexity of the burden on the health, social, economic, and cultural influences of COVID-19. In this context, all related disciplines are working together to mitigate the negative influences of the disease. In particular, health promotion, a discipline of public health, matters to the pandemic as it may address the threats at different levels. Health promotion strategies mostly use solution-oriented efforts with inter- and multidisciplinary approaches. Nevertheless, as the COVID-19 burden has many time-critical determinants, these approaches cannot be sufficient to overcome the problem. A transdisciplinary approach in its broader sense using almost all inputs to synthesize and produce an integrative solution may be extremely helpful. In this paper, the importance of transdisciplinary approaches in health promotion to combat COVID-19 has been discussed.