Comparative assessment of dermal wound healing potentials of various Trifolium L. extracts and determination of their isoflavone contents as potential active ingredients

RENDA G., Yalcin F. N., NEMUTLU E., AKKOL E., SÜNTAR İ., KELEŞ H., ...More

JOURNAL OF ETHNOPHARMACOLOGY, vol.148, no.2, pp.423-432, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 148 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jep.2013.04.031
  • Journal Name: JOURNAL OF ETHNOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.423-432
  • Keywords: Trifolium, Isoflavones, HPLC, Wound healing, Excision, Incision, PROTECTS DOPAMINERGIC-NEURONS, RED-CLOVER, LIQUID-CHROMATOGRAPHY, MEDICINAL-PLANTS, PRATENSE L., ANTIOXIDANT, PHYTOESTROGENS, IDENTIFICATION, FLAVONOIDS, GENISTEIN
  • Hacettepe University Affiliated: Yes

Abstract

Ethnopharmacological relevance: Tnfolium species are used in Turkish folk medicine as a wound healing agent, expectorant, antiseptic, sedative and to alleviate pain in rheumatism. In the present study, the aqueous methanolic extracts (80%) of 13 Trifolium species (Trifolium ambigum, Trifolium arvense var. arvense, Trifolium campestre, Trifolium canescens, Trifolium hybridum var. anatolicum, Trifolium hybridum var. hybridum, Tnfolium pannonicum, Tnfolium pratense var. pratense, Trifolium purpureum var. puipureum, Tnfolium repens var. repens, Tnfolium resupinatum var. microcephalum, Tnfolium spadiceum and Trifolium trichocephalum) collected from different regions of Anatolia were evaluated for their in vivo wound healing effects.