5-Fluorouracil intercalated iron oxide@layered double hydroxide core-shell nano-composites with isotropic and anisotropic architectures for shape-selective drug delivery applications

Tuncelli, Gulsevde; AY, AHMET; Zumreoglu-Karan, BİRGÜL

doi:10.1016/j.msec.2015.06.001

5-Fluorouracil intercalated iron oxide@layered double hydroxide core-shell nano-composites with isotropic and anisotropic architectures for shape-selective drug delivery applications

Tuncelli G., AY A. N., Zumreoglu-Karan B.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, cilt.55, ss.562-568, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 55
Basım Tarihi: 2015
Doi Numarası: 10.1016/j.msec.2015.06.001
Dergi Adı: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.562-568
Hacettepe Üniversitesi Adresli: Evet

Özet

We report the synthesis, characterization and in vitro release behavior of anti-cancer drug carrying iron oxide@ layered double hydroxide core-shell nanocomposites with sizes ranging from 40 to 300 nm, good drug loading capacities and soft ferromagnetic properties. HRTEM analyses verified that nearly spherical isotropic carriers were obtained by coating spherical magnetite particles while anisotropic carriers were obtained by coating spindle-shaped hematite particles. They both displayed a fluctuating in vitro release profile with a higher release percentage for the anisotropic carrier. (C) 2015 Elsevier B.V. All rights reserved.