IgE-mediated food allergy throughout life

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Celebioglu E., AKARSU A., ŞAHİNER Ü. M.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.51, no.1, pp.49-60, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 51 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2006-95
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.49-60
  • Keywords: Alpha-gal allergy, anaphylaxis, food allergy, food challenge, IgE, pollen food allergy, skin prick test, NATURAL-HISTORY, COWS MILK, CLINICAL REACTIVITY, ORAL IMMUNOTHERAPY, ADVERSE-REACTIONS, HAZELNUT ALLERGY, PEANUT ALLERGY, DOUBLE-BLIND, EGG ALLERGY, PREVALENCE
  • Hacettepe University Affiliated: Yes


Food allergy (FA) has become an increasing problem throughout the world. Over the last 2 decades, the frequency of FA has increased in both children and adults. The prevalence differs according to the research methodology, age, and geographic regions, ranging between 2.0% and 10.0%. The most common form of FA is immunoglobulin E (IgE)-mediated FA. In this form, patients may present with life-threatening conditions, such as anaphylaxis, or milder conditions, such as urticaria, angioedema, sneezing, and nausea alone. The gold standard in the diagnosis of FA is oral provocation tests. Epidermal skin prick tests and specific IgE measurements, as well as component-resolved diagnostic techniques are helpful in the diagnosis and follow-up of patients. In this review, the epidemiology, diagnosis, follow-up, and prognosis of IgE-mediated FA in children and adults were discussed and some specific forms of FA, such as pollen FA syndrome, alpha-gal allergy, and food-dependent exercise-induced anaphylaxis were explained.