Infantile myofibromatosis is a rare tumor of childhood, which involves the head and neck region in 30% of cases. There are 3 different types: solitary, multicentric, and multicentric with visceral involvement. Herein we describe the case of a male infant with a solitary lesion in the parapharyngeal space and to our knowledge this is the first infantile myofibromatosis case in this location. Additionally, radiological and histopathological characteristics of infantile myofibromatosis are discussed in the light of the literature. (C) 2008 Elsevier Ireland Ltd. All rights reserved.