Succinylcholine or rocuronium? A meta-analysis of the effects on intubation conditions

Karcioglu O., Arnold J. .. , Topacoglu H., Ozucelik D. N. , Kiran S., Sonmez N.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, vol.60, no.12, pp.1638-1646, 2006 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 60 Issue: 12
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1742-1241.2005.00685.x
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1638-1646


This meta-analysis was undertaken to compare the effects of succinylcholine (SCH) and rocuronium (RCR) on endotracheal intubation (ETI) conditions. Eligible randomised controlled trials (RCTs) were identified via MEDLINE and a manual search of references. The frequencies of excellent and unacceptable ETI conditions in subjects receiving SCH 1.0-1.5 mg/kg and RCR 0.6-1.2 mg/kg were determined using standard statistical methods. Inclusion criteria were met by 16 RCTs, representing 1362 subjects. SCH was associated with a 17.7% increase (95% CI = 13-22) in the frequency of excellent ETI conditions and a 5.1% decrease (95% CI = -7.3 to -2.9) in the frequency of unacceptable ETI conditions, when compared with RCR. In the subgroup undergoing true rapid sequence intubation, SCH was associated with a 19.1% increase (95% CI = 13.7-24.5) in the frequency of excellent ETI conditions. SCH appears to be superior to RCR in creating excellent ETI conditions and avoiding unacceptable ETI conditions.