Proteasome Inhibitor Bortezomib Increases Radiation Sensitivity in Androgen Independent Human Prostate Cancer Cells

Goktas, Serdar; Baran, Yusuf; Ural, Ali; Yazici, MUSTAFA; Aydur, Emin; Basal, Seref; Avcu, Ferit; Pekel, Aysel; Dirican, Bahar; Beyzadeoglu, Murat

doi:10.1016/j.urology.2009.07.1215

Proteasome Inhibitor Bortezomib Increases Radiation Sensitivity in Androgen Independent Human Prostate Cancer Cells

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Goktas S., Baran Y., Ural A. U., Yazici S., Aydur E., Basal S., ...More

UROLOGY, vol.75, no.4, pp.793-798, 2010 (SCI-Expanded)

Publication Type: Article / Article
Volume: 75 Issue: 4
Publication Date: 2010
Doi Number: 10.1016/j.urology.2009.07.1215
Journal Name: UROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.793-798
Hacettepe University Affiliated: Yes

Abstract

OBJECTIVES To investigate the effects of a strong proteasome inhibitor, bortezomib alone or in combination with radiotherapy on androgen-independent DU145 human prostate cancer cells. Proteasomes play important roles in cell cycle, proliferation, apoptosis, angiogenesis, and cellular resistance to chemotherapy and radiotherapy.