Proteasome Inhibitor Bortezomib Increases Radiation Sensitivity in Androgen Independent Human Prostate Cancer Cells

Goktas, Serdar; Baran, Yusuf; Ural, Ali; Yazici, MUSTAFA; Aydur, Emin; Basal, Seref; Avcu, Ferit; Pekel, Aysel; Dirican, Bahar; Beyzadeoglu, Murat

doi:10.1016/j.urology.2009.07.1215

Proteasome Inhibitor Bortezomib Increases Radiation Sensitivity in Androgen Independent Human Prostate Cancer Cells

Goktas S., Baran Y., Ural A. U., Yazici S., Aydur E., Basal S., ...Daha Fazla

UROLOGY, cilt.75, sa.4, ss.793-798, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 75 Sayı: 4
Basım Tarihi: 2010
Doi Numarası: 10.1016/j.urology.2009.07.1215
Dergi Adı: UROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.793-798
Hacettepe Üniversitesi Adresli: Evet

Özet

OBJECTIVES To investigate the effects of a strong proteasome inhibitor, bortezomib alone or in combination with radiotherapy on androgen-independent DU145 human prostate cancer cells. Proteasomes play important roles in cell cycle, proliferation, apoptosis, angiogenesis, and cellular resistance to chemotherapy and radiotherapy.