Proteasome Inhibitor Bortezomib Increases Radiation Sensitivity in Androgen Independent Human Prostate Cancer Cells


Goktas S., Baran Y., Ural A. U., Yazici S., Aydur E., Basal S., ...Daha Fazla

UROLOGY, cilt.75, sa.4, ss.793-798, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75 Sayı: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.urology.2009.07.1215
  • Dergi Adı: UROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.793-798
  • Hacettepe Üniversitesi Adresli: Evet

Özet

OBJECTIVES To investigate the effects of a strong proteasome inhibitor, bortezomib alone or in combination with radiotherapy on androgen-independent DU145 human prostate cancer cells. Proteasomes play important roles in cell cycle, proliferation, apoptosis, angiogenesis, and cellular resistance to chemotherapy and radiotherapy.