Proteasome Inhibitor Bortezomib Increases Radiation Sensitivity in Androgen Independent Human Prostate Cancer Cells


Goktas S., Baran Y., Ural A. U. , Yazici S. , Aydur E., Basal S., ...Daha Fazla

UROLOGY, cilt.75, sa.4, ss.793-798, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75 Konu: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.urology.2009.07.1215
  • Dergi Adı: UROLOGY
  • Sayfa Sayıları: ss.793-798

Özet

OBJECTIVES To investigate the effects of a strong proteasome inhibitor, bortezomib alone or in combination with radiotherapy on androgen-independent DU145 human prostate cancer cells. Proteasomes play important roles in cell cycle, proliferation, apoptosis, angiogenesis, and cellular resistance to chemotherapy and radiotherapy.