Clinical Significance of Serum Vascular Endothelial Growth Factor, Pigment Epithelium-Derived Factor, Tumor Necrosis Factor Alpha, and Progranulin Levels in Patients with Gastric Cancer and Gastric Precancerous Lesions

Aksoy E. K., Akpinar M. Y., Dogan O., GÖKTAŞ Z., Sapmaz F. P., Simsek G. G., ...More

JOURNAL OF GASTROINTESTINAL CANCER, vol.50, no.3, pp.537-542, 2019 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.1007/s12029-019-00251-8
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.537-542
  • Keywords: Gastric cancer, Gastric atrophy, Intestinal metaplasia, VEGF, PEDF, TNF-alpha, Progranulin, EXPRESSION, IDENTIFICATION, ANGIOGENESIS
  • Hacettepe University Affiliated: Yes


Background The purpose of this study is to evaluate serum levels of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), tumor necrosis factor alpha (TNF-alpha), and progranulin in patients with gastric cancer (GC) and precancerous lesions (PCL) and to determine the usefulness of these markers as diagnostic biomarkers in these diseases.