Background: Although mesh implementation provides better results in terms of recurrence during abdominal wall hernia repair, mesh infection is an important issue that can cause prolonged hospitalization, recurrence, and increased costs. Sometimes is not possible to treat the infection without mesh extraction. Among the various commercially available meshes, polypropylene-based non-absorbable mesh most commonly used. Mesh composition, surface properties, and textile are the mesh-related factors that contribute to infection. Bacterial properties can also contribute to infection. Additionally, inappropriate surgical technique during mesh application can be another factor facilitating infection. The aim of this study is to investigate the relationship between folding, shrinkage, and infection in polypropylene mesh that is implemented on the rat abdominal wall.