Obesity is associated with increased myocardial oxidative stress


VINCENT H., POWERS S., STEWART D., SHANELY R., Demirel H., NAITO H.

INTERNATIONAL JOURNAL OF OBESITY, vol.23, no.1, pp.67-74, 1999 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 1999
  • Doi Number: 10.1038/sj.ijo.0800761
  • Journal Name: INTERNATIONAL JOURNAL OF OBESITY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.67-74
  • Keywords: obesity, myocardium, lipid peroxidation, antioxidant enzymes, reactive oxygen species (ROS), ZUCKER-FATTY RAT, FREE-RADICALS, CELLULAR DEFENSES, SKELETAL-MUSCLE, ISCHEMIA, EXERCISE, PROTEINS, HEART, ASSAY

Abstract

OBJECTIVE: To determine: 1) whether obesity predisposes the myocardium to oxidative stress as evidenced by higher tissue levels of myocardial lipid peroxidation, and 2) what cellular mechanisms are responsible for this predisposition.