Bioengineering functional copolymers: synthesis and characterization of poly(N-isopropyl acrylamide-co-3,4-2H-dihydropyran)s


Uzgoren A., Rzaev Z. M. O., Okay G.

JOURNAL OF POLYMER RESEARCH, vol.14, no.4, pp.329-338, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1007/s10965-007-9116-8
  • Journal Name: JOURNAL OF POLYMER RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.329-338
  • Hacettepe University Affiliated: Yes

Abstract

Novel bioengineering copolymers were synthesized by radical copolymerization of N-isopropylacrylamide (NIPA) and 3,4-2H-dihydropyran (DHP) with 2,2'-azobisisobutyronitrile as an initiator in acetone solution at 70 degrees C under nitrogen atmosphere. Structure, tacticity and compositons of the copolymers prepared in a wide range of monomer feed were confirmed by FTIR, H-1{C-13} NMR-DEPT and elemental analyses. The monomer reactivity ratios (r(1) and r(2)) were detected using known two methods: r(1) (NIPA)=1.25 and r(2)=0.035 (DHP), and r(1) (NIPA) =0.97 and r(2)=0.022 (DHP) by Kelen-Tudos and Jaacks methods, respectively. It was demonstrated that the studied monomer pair has a tendency to form H-bonding beween amide/ether groups through -NE...O< complexation which played an important role in the stereoselective chain growth, and significant decrease of allyl degradative chain transfer reactions. This phenomenon is also confirmed by the observed relatively high molecular weights of copolymers (M-v). The synthesized water-soluble stimuli-responsive poly (NIPA-co-DHP)s exhibit thermal stability, higher glass-transition temperature, polyelectrolyte, pH- and temperature-sensitive behavior and can be attributed to the class of bioengineering functional copolymers useful for various bio- and gene-engineering, and drug delivery applications.