Rheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics

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Saitarly S., Pushkarev Y., Nesterkina M., Ozturk S., SALİH B., Kravchenko I.

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, cilt.12, sa.2, ss.1907-1915, 2022 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.33263/briac122.19071915
  • Dergi Adı: BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.1907-1915
  • Anahtar Kelimeler: hyaluronic acid, molecular weight, MALDI, viscosity, theological properties, technology, MOLECULAR-WEIGHT
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Rheological measurements were carried out on dilute aqueous solutions of high (HMW-HA, 1150 kDa) and low molecular eight hyaluronic acids (LMW-HA, 8 kDa) along with their mixtures to determine the relationship between the viscosity and concentration of the samples, Molecular weight and polydispersity of low molecular HA have been determined by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). HA diluted solutions ere found to be weakly structured liquids with a slight viscosity anomaly. Critical aloes of concentration ere determined at different ratios of HMW-HA and LMW-HA leading to a sharp increase in the viscosity of solutions. Rheological studies have proved the pseudoplastic nature of the viscous flow of HMW-HA solutions. The possibility of using the Ostwald-de Wale equation for the mathematical description of a viscous flow was established. The results of the 'theological analysis might be applied for the rational development of cosmetic formulations containing hyaluronic acid of various molecular weights.