Oxidative stress in asthma

Sahiner Ü. M., Birben E., Erzurum S., Sackesen C., Kalayci O.

World Allergy Organization Journal, vol.4, no.10, pp.151-158, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 4 Issue: 10
  • Publication Date: 2011
  • Doi Number: 10.1097/wox.0b013e318232389e
  • Journal Name: World Allergy Organization Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.151-158
  • Keywords: asthma, oxidative stress, reactive oxygen species, redox, ORAL N-ACETYLCYSTEINE, EXTRACELLULAR GLUTATHIONE-PEROXIDASE, OBSTRUCTIVE PULMONARY-DISEASE, EXHALED BREATH CONDENSATE, DIESEL EXHAUST PARTICLES, SUPEROXIDE-DISMUTASE, NITRIC-OXIDE, AIRWAY INFLAMMATION, EPITHELIAL-CELLS, EOSINOPHIL PEROXIDASE
  • Hacettepe University Affiliated: Yes

Abstract

Asthma is a chronic inflammatory lung disease that results in airflow limitation, hyperreactivity, and airway remodeling. There is strong evidence that an imbalance between the reducing and oxidizing systems favoring a more oxidative state is present in asthma. Endogenous and exogenous reactive oxygen species, such as superoxide anion, hydroxyl radical, hypohalite radical, and hydrogen peroxide, and reactive nitrogen species, such as nitric oxide, peroxynitrite, and nitrite, play a major role in the airway inflammation and are determinants of asthma severity. Asthma is also associated with decreased antioxidant defenses, such as superoxide dismutase, catalase, and glutathione. In this review, we will summarize the current knowledge and discuss the current and future strategies for the modulation of oxidative stress in asthma. Copyright © 2011 by World Allergy Organization.