Long-term survival in severe combined immune deficiency: The role of persistent maternal engraftment

Tezcan I., Ersoy F., Sanal O., Turul T., Uckan D., Balci S., ...More

JOURNAL OF PEDIATRICS, vol.146, no.1, pp.137-140, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 146 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1016/j.jpeds.2004.09.010
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.137-140
  • Hacettepe University Affiliated: Yes


Two siblings with severe combined immune deficiency, one with maternal engraftment and detectable immunologic functions who was alive at the age of 8 years are presented. Both patients had the same. JAK3 gene mutation, suggesting that maternal engraftment may result in immune competence leading to long-term survival in patients with severe combined immune deficiency.