Formulation studies for mirtazapine orally disintegrating tablets

YILDIZ S., AYTEKİN E., Yavuz B., Pehlivan S., UNLU N.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, cilt.42, sa.6, ss.1008-1017, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/03639045.2015.1104345
  • Dergi Adı: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1008-1017
  • Anahtar Kelimeler: microencapsulation, Formulation development, taste masking, mirtazapine, orally disintegrating tablets, TASTE MASKING, PHARMACOKINETICS, PROFILE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: Orally disintegrating tablets (ODTs) recently have gained much attention to fulfill the needs for pediatric, geriatric, and psychiatric patients with dysphagia. Aim of this study was to develop new ODT formulations containing mirtazapine, an antidepressant drug molecule having bitter taste, by using simple and inexpensive preparation methods such as coacervation, direct compression and to compare their characteristics with those of reference product (Remereon SolTab).