Short-term treadmill exercise in a cold environment does not induce adrenal Hsp72 and Hsp25 expression


AKIN Ş., NAITO H., Ogura Y., ICHINOSEKI-SEKINE N., KUROSAKA M., KAKIGI R., ...More

JOURNAL OF PHYSIOLOGICAL SCIENCES, vol.67, no.3, pp.407-413, 2017 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1007/s12576-016-0473-0
  • Journal Name: JOURNAL OF PHYSIOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.407-413
  • Keywords: Hsp72, Hsp25, Cold exercise, Adrenal, Treadmill running, HEAT-SHOCK PROTEINS, ISCHEMIA-REPERFUSION, MYOCARDIAL TOLERANCE, SKELETAL-MUSCLE, MOUSE SKELETAL, IN-VIVO, STRESS, RATS, HYPERTHERMIA, AXIS

Abstract

Heat shock proteins (Hsps) have a critical role in maintaining cellular homeostasis and in protecting cells from a range of acute and chronic stressful conditions. Treadmill running exercise results in increased Hsp72 and Hsp25 levels in various tissues and heat production during exercise has been shown to be the main factor for the increased levels of Hsp72 in myocardium. Since the adrenal gland plays a vital role in general response to stress, regulation of Hsps in adrenal glands following stressful events seems to be critical for controlling the whole-body stress response appropriately. This study tested the hypothesis of whether elevation of temperature is solely responsible for exercise-induced adrenal Hsp72 and Hsp25 expression. Female Sprague-Dawley rats (3 months old) were randomly assigned to either a sedentary control group or one of two treadmill-running groups: a cold exercise group run in a cold room at 4 A degrees C (CE), and a warm exercise group run at 25 A degrees C temperature (WE). Animals were run 60 min a day at 30 m min(-1) speed for 4 consecutive days following adaptation to treadmill exercise. Exercise resulted in a significant elevation of body temperature only in the WE group (p < 0.05). Adrenal Hsp72 and Hsp25 levels were significantly higher in the WE group compare to the other groups (p < 0.05). These data demonstrated that exercise-related elevations of body temperature could be the only factor for the inductions of adrenal Hsp72 and Hsp25 expression.