Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors

Thaker P., Yazici S., Nilsson M., Yokoi K., Tsan R., He J., ...More

CLINICAL CANCER RESEARCH, vol.11, no.13, pp.4923-4933, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 13
  • Publication Date: 2005
  • Doi Number: 10.1158/1078-0432.ccr-04-2060
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4923-4933
  • Hacettepe University Affiliated: Yes


Purpose: We determined whether the administration of the tyrosine kinase inhibitor, AEE788, which targets the epidermal growth factor receptor and the vascular endothelial growth factor receptor, alone or in combination with paclitaxel, can inhibit progressive growth of human ovarian carcinoma in the peritoneal cavity of female nude mice.