Infantile atopic dermatitis: Serum vitamin D, zinc and TARC levels and their relationship with disease phenotype and severity

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ESENBOĞA S., Sahiner N., Birben E., UYSAL SOYER Ö., ŞEKEREL B. E., ŞAHİNER Ü. M.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, vol.49, no.3, pp.162-168, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.15586/aei.v49i3.191
  • Journal Name: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, DIALNET
  • Page Numbers: pp.162-168
  • Keywords: atopic dermatitis, infant, objective SCORAD, TARC, vitamin D, 0-1 year, ACTIVATION-REGULATED CHEMOKINE, CHILDREN, THYMUS, AGE
  • Hacettepe University Affiliated: Yes

Abstract

Background: Several markers that influence the clinical course of atopic dermatitis (AD) have been investigated so far. Thymus and activation regulated chemokine (TARC) - a Th2-related cytokine - increase in various atopic diseases. It has been shown that vitamin D affects Treg cells and immune responses. Zinc as an essential trace element for cell-cell interactions, cellular differentiation, and proliferation. However, the effect of these markers on infantile AD and disease severity are mostly unknown.