CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T-1 breast cancer


Cabioglu N., Yazici M. S. , Arun B., Broglio K., Hortobagyi G., Price J., ...More

CLINICAL CANCER RESEARCH, vol.11, no.16, pp.5686-5693, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 16
  • Publication Date: 2005
  • Doi Number: 10.1158/1078-0432.ccr-05-0014
  • Journal Name: CLINICAL CANCER RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.5686-5693
  • Hacettepe University Affiliated: Yes

Abstract

Purpose: The chemokine receptors CCR7 and CXCR4 have been shown to play an important role in cancer metastasis. We therefore studied the differential expression of CCR7 and CXCR4, along with that of the biomarker HER2-neu, to evaluate whether these biomarkers could predict axillary lymph node metastasis in breast cancer.