The Role of Statins in Sepsis


Goncuoglu C., Cetinadam H. N. , Demirkan K., ÜNAL S.

FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, vol.26, no.3, pp.369-377, 2021 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Review
  • Volume: 26 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5578/flora.20219704
  • Journal Name: FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
  • Journal Indexes: Emerging Sources Citation Index, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.369-377
  • Keywords: Sepsis, Septic shock, Statin, Antiinflammatory effect, Pleiotropic effect, MULTIPLE ORGAN DYSFUNCTION, NITRIC-OXIDE SYNTHASE, DOUBLE-BLIND, KAPPA-B, THERAPY, MORTALITY, INFECTION, CAMPAIGN, PROTEIN, SHOCK

Abstract

Sepsis is defined as organ dysfunction due to an irregular host response to infection caused by bacteria, viruses, parasites or fungal microorganisms and may cause morbidity or mortality. The benefit of statins in atherosclerosis and various cardiovascular diseases is explained by their positive effect on the endothelium by lowering high cholesterol levels. Statins have pleiotropic effects such as anti-inflammatory, antithrombotic and antioxidant effects in addition to their lipid lowering effects. It has been shown that pretreatment with statins may affect survival in sepsis. In sepsis and septic shock, cytokine release from endothelial cells, procoagulant molecules and thrombocyte production are encouraged. In addition, with the development of inflammation in sepsis, vascular permeability increases in the infected tissue due to the increase of neutrophils and phagocytes and tissue damage occurs. Thus, homeostasis regulating vascular tone is disturbed and endothelial damage is formed. Statins act on sepsis by providing vascular relaxation in the endothelium and re-ducing the expression of adhesion molecules and cytokines. In the light of current knowledge, more comprehensive studies are needed to recommend the use of statins to benefit from its pleiotropic effects in the treatment of sepsis.