The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma - Correlations with clinical features

Guler G., ÜNER A., Guler N., Han S., Iliopoulos D., Hauck W., ...Daha Fazla

CANCER, cilt.100, sa.8, ss.1605-1614, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 100 Sayı: 8
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1002/cncr.20137
  • Dergi Adı: CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1605-1614
  • Hacettepe Üniversitesi Adresli: Evet

Özet

BACKGROUND. FHIT and WWOX are a tumor suppressor and a candidate suppressor that encompass the FRA3B and FRA16D fragile sites at chromosomes 3p14.2 and 16q23.3-24.1, respectively. Reduced or absent Fhit expression has been reported in two-thirds of invasive breast tumors in association with adverse prognostic factors. Loss of 16q has been reported frequently in low-grade, invasive breast tumors.