Real-world data on MTX tolerance with regimens used in children versus adults

KAYA AKCA Ü., Farisogullari B., YARDIMCI G. K., SAĞ E., ATALAY E., KASAP CÜCEOĞLU M., ...More

CLINICAL RHEUMATOLOGY, vol.40, no.12, pp.5095-5102, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 12
  • Publication Date: 2021
  • Doi Number: 10.1007/s10067-021-05802-8
  • Journal Name: CLINICAL RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.5095-5102
  • Keywords: Methotrexate, Intolerance, Methotrexate intolerance severity score, JUVENILE IDIOPATHIC ARTHRITIS, METHOTREXATE INTOLERANCE, RHEUMATOID-ARTHRITIS, PARENTERAL METHOTREXATE, FOLINIC ACID, RISK-FACTORS, TOXICITY, SUPPLEMENTATION, PREVALENCE, THERAPY
  • Hacettepe University Affiliated: Yes

Abstract

Objective Methotrexate (MTX) is one of the most commonly used disease-modifying anti-rheumatic drugs which can cause gastrointestinal side effects. MTX intolerance is defined as gastrointestinal and behavioral symptoms occurring before and after MTX administration. This study aims to evaluate and compare the frequency of methotrexate intolerance in adult and pediatric patients.