Reduced irisin levels in patients with acromegaly


Şendur S. N. , Baykal G., Fırlatan B., Aydin B., Lay İ., Dağdelen S., ...More

HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION, 2022 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1515/hmbci-2022-0009
  • Journal Name: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
  • Journal Indexes: Emerging Sources Citation Index, Scopus, Academic Search Premier, Chemical Abstracts Core, EMBASE, MEDLINE
  • Keywords: acromegaly, FNDC5 polymorphism, irisin, somatostatin receptor ligand, ADIPOSE-TISSUE, DIABETES-MELLITUS, FNDC5, METABOLISM, GLUCOSE, GENE, CONSENSUS, CRITERIA, SERUM, CURE

Abstract

Objectives: Several metabolic disturbances are seen in acromegaly however, data regarding the contribution of irisin to these disturbances is currently insufficient. In a cohort of patients with acromegaly, we measured serum irisin levels in active and controlled cases and determined independent factors that effect serum irisin including fibronectin type III domain-containing protein 5 (FNDC5) genotyping.