Thrombocytopenia complicating the clinical course of leptospiral infection

Turgut M., Sunbul M., Bayirli D., Bilge A., Leblebicioglu H., Haznedaroglu I.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.30, no.5, pp.535-540, 2002 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 5
  • Publication Date: 2002
  • Doi Number: 10.1177/147323000203000511
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.535-540


Leptospirosis can present with a wide clinical spectrum, and haematological manifestations are often apparent. We retrospectively analysed platelet counts in 49 patients with leptospirosis. Forty-three patients (87.8%) had thrombocytopenia. Mean baseline platelet counts rose from 69 x 10(9)/1 to 151 x 10(9)/1 following treatment. Haemorrhagic episodes were observed in 11 patients. Platelet nadir was 29 x 10(9)/1 in the group experiencing bleeding and 64 x 10(9)/1 in the remainder. Six patients died due to bleeding and one due to sepsis. Thirty-six patients (73.5%) had acute renal failure; their mean platelet count was 46 x 10(9)/1. Liver enzyme levels were elevated in all patients. Thrombocyte count, liver enzyme levels and bilirubin levels were significantly correlated. Forty-three (87.8%) patients showed signs of sepsis; mean thrombocyte count was 46 x 10(9)/1 in these patients, and 133 x 10(9)/1 in those without sepsis. Multiple organ involvement and fulminant disease is usually associated with renal failure and/or thrombocytopenia in leptospirosis.