Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Pediatri, cilt.31, sa.2, ss.67-73, 2022 (Scopus)
Copyright © 2022 by Türkiye Klinikleri.Objective: It is known that bone health is impaired in anorexia nervosa (AN), especially due to low body weight. Rapid and severe weight loss and long-term nutritional deficiency might adversely affect bone health in atypical AN (AAN), despite the normal weight status. We aimed to compare the bone mineral density (BMD) parameters and clinical factors that may affect bone health in adolescents with AN and AAN. Material and Methods: The clinical data of 60 AN and 30 AAN patients, aged 11-18 years, who were followed up in our clinic between 2014 and 2018 and had a dual-energy X-ray absorptiometry assessment were retrospectively evaluated. The control group included 20 healthy adolescents without any chronic disease and regular drug use. Results: We found that the femoral neck (p=0.001) and lumbar spine (p=0.004) z scores of the AN group were significantly lower than the AAN group. No significant difference was found between the AAN and the control groups. On the other hand, in adolescents with AAN compared to the control group, the ratio of low BMD (z score ≤2, p=0.0018) and low BMD risk (z score ≤1, p=0.0036) were higher. While obesity history was higher in the AAN group compared to AN, the rate and percentage of weight loss were similar between the two groups. Conclusion: Although, we showed that AN and AAN are clinically similar in terms of weight loss severity and nutritional deficiency; BMD z scores of AAN patients were not lower than controls. However, low BMD risk was higher in AAN compared to the control group. These findings suggest that despite protective factors of AAN, such as higher obesity history and absence of amenorrhea, adolescents with AAN are also at risk for bone health.