Early Diagnosis of Distal Peripheral Polyneuropathy Due to Glucose Metabolism Disorders via Intraepidermal Nerve Fiber Analysis

Kursun O., KARATAŞ KURŞUN H., ULUÇ K., ERDEM ÖZDAMAR S., Erbas T., Tan E.

TURKISH JOURNAL OF NEUROLOGY, vol.15, no.1, pp.24-30, 2009 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 2009
  • Journal Name: TURKISH JOURNAL OF NEUROLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.24-30
  • Hacettepe University Affiliated: Yes

Abstract

Objective: Polyneuropathy is the most frequent complication of diabetes mellitus (DM), which is a common disorder worldwide. Early diagnosis of this complication is critical for treatment planning. Recently, intra-epidermal nerve fiber (IENF) analysis has been used for the early diagnosis of diabetic neuropathy and was reported to be superior to both conventional fascicular nerve biopsy and other diagnostic tests. The present study aimed to determine the effect of early glucose metabolism disorders on the peripheral nerves using IENF analysis.