Chitosan delivery systems for the treatment of oral mucositis: in vitro and in vivo studies.


Aksungur P., Sungur A., Unal S., Iskit A. B. , Squier C., Senel S.

Journal of controlled release : official journal of the Controlled Release Society, vol.98, no.2, pp.269-79, 2004 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1016/j.jconrel.2004.05.002
  • Journal Name: Journal of controlled release : official journal of the Controlled Release Society
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.269-79
  • Keywords: chitosan, nystatin, oral mucositis, gel, film, in vivo studies, DRUG-DELIVERY, CONTROLLED-RELEASE, MOLECULAR-WEIGHT, BIOADHESIVE, HYDROGELS, COMPLEX, CAVITY, BEADS

Abstract

Oral mucositis is a frequent and potentially severe complication of radiation or chemotherapy for cancer. Associated with atrophy and ulceration of the oral mucosa is an increased risk of infection, and the most common pathogenic agent is Candida. Chitosan is an excellent candidate for the treatment of oral mucositis. Its bioadhesive and antimicrobial properties offer the palliative effects of an occlusive dressing and the potential for delivering drugs, including anti-candidal agents.