Evaluation of cardiovascular complications with Tc-99m tetrofosmin gated myocardial perfusion scintigraphy in patients with thalassernia major


Gedik G. K. , Caglar M., ÜNAL S., Gumruk F.

REVISTA ESPANOLA DE MEDICINA NUCLEAR, vol.27, no.3, pp.191-198, 2008 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1157/13121029
  • Journal Name: REVISTA ESPANOLA DE MEDICINA NUCLEAR
  • Journal Indexes: Science Citation Index Expanded, Scopus, DIALNET
  • Page Numbers: pp.191-198
  • Keywords: thalassemia major, cardiac toxicity, atherosclerosis, Tc-99m tetrofosmin, scintigraphy, LEFT-VENTRICULAR FUNCTION, BETA-THALASSEMIA, IRON OVERLOAD, ATHEROSCLEROTIC LESIONS, CARDIOMYOPATHY, ECHOCARDIOGRAPHY, SPECT, DYSFUNCTION, TOMOGRAPHY, INFARCTION

Abstract

Objective. Iron overload limits the life expectancy of thalassaemic patients by causing cardiac toxicity. Iron also plays a catalytic role in the pathogenesis of atherosclerosis. The aim of this study was to evaluate the role of Tc-99m Tetrofosmin gated myocardial perfusion scintigraphy (GMPS) in the detection of cardiac dysfunction in patients with thalassemia major.