Topics of respiration and energy acquisition are two of the topics which students consider as difficult and have the least interest in. For that reason, in this research, it was aimed to determine the contexts and study methods that could influence the student success and learning motivation positively. Data were collected by means of a questionnaire form regarding the interest in the various contexts of the topic and in the activities which can be made in the course process. Study group of the research is made up of 173 students who study in 11th and 12th grades in German state of Schleswig-Holstein. Research results indicated that even though the general interest of the students in the subject was little, the interest of the Students increased when the topic was associated with various contexts. The interest is at its highest level within the contexts of health, sport and human biology. The activities in which the interests of the students are highest are the ones supported by visual-auditory materials in which students take part in actively or as observers. Research results include tips which will be helpful in preparation of the course contents in which context-based learning is grounded on.