Long-term Dexamethasone Treatment Increases Cardiac Galectin-3 Levels.

Akin Ş., Gucuk-Ipek E., Hayta U., Gungor I., Kubat G. B., Akin Y., ...Daha Fazla

Cardiovascular drugs and therapy, cilt.37, sa.5, ss.1027-1029, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 5
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s10557-022-07344-w
  • Dergi Adı: Cardiovascular drugs and therapy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1027-1029
  • Anahtar Kelimeler: Glucocorticoids, Galectin-3, Cardiac fibrosis, Cardiomyocyte, HYPERTROPHY
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose Glucocorticoids, which are widely prescribed around the world, cause cardiac remodeling in long-term treatment by triggering insulin resistance and increasing blood pressure. However, its role in cardiac remodeling remains unclear. Galectin-3 (gal-3) is a member of a beta-galactoside-binding animal lectins, upregulated as a result of insulin resistance and in the pressure-overloaded myocardium and regulate cardiac remodeling. We hypothesized that gal-3 may be upregulated in the myocardium with prolonged use of glucocorticoids and associated with cardiac hypertrophy.