Long-term Dexamethasone Treatment Increases Cardiac Galectin-3 Levels.


Akin Ş., Gucuk-Ipek E., Hayta U., Gungor I., Kubat G. B. , Akin Y., ...More

Cardiovascular drugs and therapy, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2022
  • Doi Number: 10.1007/s10557-022-07344-w
  • Journal Name: Cardiovascular drugs and therapy
  • Journal Indexes: Science Citation Index Expanded, Scopus, PASCAL, BIOSIS, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Glucocorticoids, Galectin-3, Cardiac fibrosis, Cardiomyocyte, HYPERTROPHY

Abstract

Purpose Glucocorticoids, which are widely prescribed around the world, cause cardiac remodeling in long-term treatment by triggering insulin resistance and increasing blood pressure. However, its role in cardiac remodeling remains unclear. Galectin-3 (gal-3) is a member of a beta-galactoside-binding animal lectins, upregulated as a result of insulin resistance and in the pressure-overloaded myocardium and regulate cardiac remodeling. We hypothesized that gal-3 may be upregulated in the myocardium with prolonged use of glucocorticoids and associated with cardiac hypertrophy.