Impact of mannose-binding lectin 2 gene polymorphisms on disease severity in noncystic fibrosis bronchiectasis in children

Dogru D., Polat S. E., Tan Ç., Tezcan İ., Yalçın S. S., Utine E., ...More

PEDIATRIC PULMONOLOGY, vol.55, no.5, pp.1190-1198, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.1002/ppul.24711
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1190-1198
  • Keywords: children, gene polymorphism, mannose-binding lectin, noncystic fibrosis bronchiectasis, CYSTIC-FIBROSIS, DEFICIENCY, SYSTEM
  • Hacettepe University Affiliated: Yes


Background Mannose-binding lectin (MBL) is a complement protein involved in the innate immune system, and is associated with some chronic respiratory diseases including noncystic fibrosis (non-CF) bronchiectasis in adults. The aim of this study was to investigate the frequency of MBL2 gene polymorphisms in children with non-CF bronchiectasis, and the effect of MBL deficiency on disease severity.