ALOX5 promoter genotype, asthma severity and LTC4 production by eosinophils

KALAYCI Ö., Birben E., Sackesen C., KESKİN Ö., TAHAN F., WECHSLER M. E., ...More

ALLERGY, vol.61, no.1, pp.97-103, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.1111/j.1398-9995.2006.00979.x
  • Journal Name: ALLERGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.97-103
  • Hacettepe University Affiliated: Yes


Background: The number of Sp1-Egr1 binding tandem repeats at the ALOX5 promoter influences gene transcription and may modify the response to anti-leukotriene treatment. The relationship of ALOX5 variants to asthma severity and leukotriene production by eosinophils is unknown.