Post-stroke inflammatory response is linked to volume loss in the contralateral hemisphere.

Okar S., TOPÇUOĞLU M. A., Yemisci M., Aktas C., Oguz K. K., ARSAVA E. M.

Journal of neuroimmunology, vol.344, pp.577247, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 344
  • Publication Date: 2020
  • Doi Number: 10.1016/j.jneuroim.2020.577247
  • Journal Name: Journal of neuroimmunology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Page Numbers: pp.577247
  • Keywords: Cerebrovascular diseases, Immunology, Infections, Neuroimaging, Strokes, ISCHEMIC-STROKE, MOTOR RECOVERY, BRAIN, IMMUNE, INJURY, CLASSIFICATION, PATHOLOGY, OUTCOMES, ATROPHY, PROTEIN
  • Hacettepe University Affiliated: Yes

Abstract

Objectives: There is a delicate homeostatic balance between the central nervous system and immune system. Stroke triggers an immunodepressive state to suppress a potential immune reaction directed against neuroglial tissue; however, this supposedly protective response inadvertently results in an infection-prone, and thereby a pro-inflammatory setting. In this study, we assessed the magnitude of cerebral volume loss in the unaffected contralateral hemisphere following stroke, and determined its relationship with inflammatory cascades.